Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.
Identifieur interne : 000019 ( Main/Exploration ); précédent : 000018; suivant : 000020Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.
Auteurs : Cherie L. Stabler [États-Unis] ; Jaime A. Giraldo [États-Unis] ; Dora M. Berman [États-Unis] ; Kerim M. Gattás-Asfura [États-Unis] ; Melissa A. Willman [États-Unis] ; Alexander Rabassa [États-Unis] ; James Geary [États-Unis] ; Waldo Diaz [États-Unis] ; Norman M. Kenyon [États-Unis] ; Norma S. Kenyon [États-Unis]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2020.
Abstract
Islet cell transplantation can lead to insulin independence, reduced hypoglycemia, and amelioration of diabetes complications in patients with type 1 diabetes. The systemic delivery of anti-inflammatory agents, while considered crucial to limit the early loss of islets associated with intrahepatic infusion, increases the burden of immunosuppression. In an effort to decrease the pharmaceutical load to the patient, we modified the pancreatic islet surface with long-chain poly(ethylene glycol) (PEG) to mitigate detrimental host-implant interactions. The effect of PEGylation on islet engraftment and long-term survival was examined in a robust nonhuman primate model via three paired transplants of dosages 4300, 8300, and 10 000 islet equivalents per kg body weight. A reduced immunosuppressive regimen of anti-thymocyte globulin induction plus tacrolimus in the first posttransplant month followed by maintenance with sirolimus monotherapy was employed. To limit transplant variability, two of the three pairs were closely MHC-matched recipients and received MHC-disparate PEGylated or untreated islets isolated from the same donors. Recipients of PEGylated islets exhibited significantly improved early c-peptide levels, reduced exogenous insulin requirements, and superior glycemic control, as compared to recipients of untreated islets. These results indicate that this simple islet modification procedure may improve islet engraftment and survival in the setting of reduced immunosuppression.
DOI: 10.1111/ajt.15643
PubMed: 31597005
PubMed Central: PMC7042048
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.</title><author><name sortKey="Stabler, Cherie L" sort="Stabler, Cherie L" uniqKey="Stabler C" first="Cherie L" last="Stabler">Cherie L. Stabler</name><affiliation wicri:level="2"><nlm:affiliation>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Giraldo, Jaime A" sort="Giraldo, Jaime A" uniqKey="Giraldo J" first="Jaime A" last="Giraldo">Jaime A. Giraldo</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Berman, Dora M" sort="Berman, Dora M" uniqKey="Berman D" first="Dora M" last="Berman">Dora M. Berman</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Surgery, Miller School of Medicine, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Surgery, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Gattas Asfura, Kerim M" sort="Gattas Asfura, Kerim M" uniqKey="Gattas Asfura K" first="Kerim M" last="Gattás-Asfura">Kerim M. Gattás-Asfura</name><affiliation wicri:level="2"><nlm:affiliation>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Willman, Melissa A" sort="Willman, Melissa A" uniqKey="Willman M" first="Melissa A" last="Willman">Melissa A. Willman</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Rabassa, Alexander" sort="Rabassa, Alexander" uniqKey="Rabassa A" first="Alexander" last="Rabassa">Alexander Rabassa</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Geary, James" sort="Geary, James" uniqKey="Geary J" first="James" last="Geary">James Geary</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Diaz, Waldo" sort="Diaz, Waldo" uniqKey="Diaz W" first="Waldo" last="Diaz">Waldo Diaz</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Kenyon, Norman M" sort="Kenyon, Norman M" uniqKey="Kenyon N" first="Norman M" last="Kenyon">Norman M. Kenyon</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Kenyon, Norma S" sort="Kenyon, Norma S" uniqKey="Kenyon N" first="Norma S" last="Kenyon">Norma S. Kenyon</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Surgery, Miller School of Medicine, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Surgery, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Biomedical Engineering, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Biomedical Engineering, University of Miami, Miami</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:31597005</idno><idno type="pmid">31597005</idno><idno type="doi">10.1111/ajt.15643</idno><idno type="pmc">PMC7042048</idno><idno type="wicri:Area/Main/Corpus">000181</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000181</idno><idno type="wicri:Area/Main/Curation">000181</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000181</idno><idno type="wicri:Area/Main/Exploration">000181</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.</title><author><name sortKey="Stabler, Cherie L" sort="Stabler, Cherie L" uniqKey="Stabler C" first="Cherie L" last="Stabler">Cherie L. Stabler</name><affiliation wicri:level="2"><nlm:affiliation>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Giraldo, Jaime A" sort="Giraldo, Jaime A" uniqKey="Giraldo J" first="Jaime A" last="Giraldo">Jaime A. Giraldo</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Berman, Dora M" sort="Berman, Dora M" uniqKey="Berman D" first="Dora M" last="Berman">Dora M. Berman</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Surgery, Miller School of Medicine, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Surgery, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Gattas Asfura, Kerim M" sort="Gattas Asfura, Kerim M" uniqKey="Gattas Asfura K" first="Kerim M" last="Gattás-Asfura">Kerim M. Gattás-Asfura</name><affiliation wicri:level="2"><nlm:affiliation>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Willman, Melissa A" sort="Willman, Melissa A" uniqKey="Willman M" first="Melissa A" last="Willman">Melissa A. Willman</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Rabassa, Alexander" sort="Rabassa, Alexander" uniqKey="Rabassa A" first="Alexander" last="Rabassa">Alexander Rabassa</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Geary, James" sort="Geary, James" uniqKey="Geary J" first="James" last="Geary">James Geary</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Diaz, Waldo" sort="Diaz, Waldo" uniqKey="Diaz W" first="Waldo" last="Diaz">Waldo Diaz</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Kenyon, Norman M" sort="Kenyon, Norman M" uniqKey="Kenyon N" first="Norman M" last="Kenyon">Norman M. Kenyon</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Kenyon, Norma S" sort="Kenyon, Norma S" uniqKey="Kenyon N" first="Norma S" last="Kenyon">Norma S. Kenyon</name><affiliation wicri:level="2"><nlm:affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Diabetes Research Institute, University of Miami, Miami</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Surgery, Miller School of Medicine, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Surgery, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:affiliation>Biomedical Engineering, University of Miami, Miami, Florida.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Biomedical Engineering, University of Miami, Miami</wicri:cityArea></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Islet cell transplantation can lead to insulin independence, reduced hypoglycemia, and amelioration of diabetes complications in patients with type 1 diabetes. The systemic delivery of anti-inflammatory agents, while considered crucial to limit the early loss of islets associated with intrahepatic infusion, increases the burden of immunosuppression. In an effort to decrease the pharmaceutical load to the patient, we modified the pancreatic islet surface with long-chain poly(ethylene glycol) (PEG) to mitigate detrimental host-implant interactions. The effect of PEGylation on islet engraftment and long-term survival was examined in a robust nonhuman primate model via three paired transplants of dosages 4300, 8300, and 10 000 islet equivalents per kg body weight. A reduced immunosuppressive regimen of anti-thymocyte globulin induction plus tacrolimus in the first posttransplant month followed by maintenance with sirolimus monotherapy was employed. To limit transplant variability, two of the three pairs were closely MHC-matched recipients and received MHC-disparate PEGylated or untreated islets isolated from the same donors. Recipients of PEGylated islets exhibited significantly improved early c-peptide levels, reduced exogenous insulin requirements, and superior glycemic control, as compared to recipients of untreated islets. These results indicate that this simple islet modification procedure may improve islet engraftment and survival in the setting of reduced immunosuppression.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">31597005</PMID><DateRevised><Year>2020</Year><Month>05</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-6143</ISSN><JournalIssue CitedMedium="Internet"><Volume>20</Volume><Issue>3</Issue><PubDate><Year>2020</Year><Month>03</Month></PubDate></JournalIssue><Title>American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</Title><ISOAbbreviation>Am J Transplant</ISOAbbreviation></Journal><ArticleTitle>Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.</ArticleTitle><Pagination><MedlinePgn>689-700</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/ajt.15643</ELocationID><Abstract><AbstractText>Islet cell transplantation can lead to insulin independence, reduced hypoglycemia, and amelioration of diabetes complications in patients with type 1 diabetes. The systemic delivery of anti-inflammatory agents, while considered crucial to limit the early loss of islets associated with intrahepatic infusion, increases the burden of immunosuppression. In an effort to decrease the pharmaceutical load to the patient, we modified the pancreatic islet surface with long-chain poly(ethylene glycol) (PEG) to mitigate detrimental host-implant interactions. The effect of PEGylation on islet engraftment and long-term survival was examined in a robust nonhuman primate model via three paired transplants of dosages 4300, 8300, and 10 000 islet equivalents per kg body weight. A reduced immunosuppressive regimen of anti-thymocyte globulin induction plus tacrolimus in the first posttransplant month followed by maintenance with sirolimus monotherapy was employed. To limit transplant variability, two of the three pairs were closely MHC-matched recipients and received MHC-disparate PEGylated or untreated islets isolated from the same donors. Recipients of PEGylated islets exhibited significantly improved early c-peptide levels, reduced exogenous insulin requirements, and superior glycemic control, as compared to recipients of untreated islets. These results indicate that this simple islet modification procedure may improve islet engraftment and survival in the setting of reduced immunosuppression.</AbstractText><CopyrightInformation>© 2019 The American Society of Transplantation and the American Society of Transplant Surgeons.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stabler</LastName><ForeName>Cherie L</ForeName><Initials>CL</Initials><Identifier Source="ORCID">0000-0003-0573-0646</Identifier><AffiliationInfo><Affiliation>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giraldo</LastName><ForeName>Jaime A</ForeName><Initials>JA</Initials><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Berman</LastName><ForeName>Dora M</ForeName><Initials>DM</Initials><Identifier Source="ORCID">0000-0001-7817-9387</Identifier><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Surgery, Miller School of Medicine, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gattás-Asfura</LastName><ForeName>Kerim M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Willman</LastName><ForeName>Melissa A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rabassa</LastName><ForeName>Alexander</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Geary</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diaz</LastName><ForeName>Waldo</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kenyon</LastName><ForeName>Norman M</ForeName><Initials>NM</Initials><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kenyon</LastName><ForeName>Norma S</ForeName><Initials>NS</Initials><Identifier Source="ORCID">0000-0003-3157-339X</Identifier><AffiliationInfo><Affiliation>Diabetes Research Institute, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Surgery, Miller School of Medicine, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Microbiology and Immunology, Miller School of Medicine, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Biomedical Engineering, University of Miami, Miami, Florida.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>P01 AI089556</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><Agency>Diabetes Research Institute Foundation</Agency><Country>International</Country></Grant><Grant><GrantID>R01 DK100654</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI102456</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2019</Year><Month>11</Month><Day>13</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Am J Transplant</MedlineTA><NlmUniqueID>100968638</NlmUniqueID><ISSNLinking>1600-6135</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">animal models: nonhuman primate</Keyword><Keyword MajorTopicYN="Y">basic (laboratory) research/science</Keyword><Keyword MajorTopicYN="Y">immunosuppression/immune modulation</Keyword><Keyword MajorTopicYN="Y">immunosuppressive regimens</Keyword><Keyword MajorTopicYN="Y">islet transplantation</Keyword><Keyword MajorTopicYN="Y">islets of Langerhans</Keyword><Keyword MajorTopicYN="Y">translational research/science</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>07</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2019</Year><Month>09</Month><Day>19</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>09</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2021</Year><Month>03</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31597005</ArticleId><ArticleId IdType="doi">10.1111/ajt.15643</ArticleId><ArticleId IdType="pmc">PMC7042048</ArticleId><ArticleId IdType="mid">NIHMS1054448</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Int J Endocrinol. 2014;2014:451035</Citation><ArticleIdList><ArticleId IdType="pubmed">24883060</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplantation. 2008 Dec 27;86(12):1658-65</Citation><ArticleIdList><ArticleId IdType="pubmed">19104401</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2007 Apr;28(11):1957-66</Citation><ArticleIdList><ArticleId IdType="pubmed">17188350</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplantation. 2007 Aug 15;84(3):308-15</Citation><ArticleIdList><ArticleId IdType="pubmed">17700154</ArticleId></ArticleIdList></Reference><Reference><Citation>EBioMedicine. 2016 Oct;12:255-262</Citation><ArticleIdList><ArticleId IdType="pubmed">27592597</ArticleId></ArticleIdList></Reference><Reference><Citation>Langmuir. 2005 Dec 20;21(26):12327-32</Citation><ArticleIdList><ArticleId IdType="pubmed">16343010</ArticleId></ArticleIdList></Reference><Reference><Citation>J Control Release. 2001 May 14;72(1-3):217-24</Citation><ArticleIdList><ArticleId IdType="pubmed">11390000</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7566-71</Citation><ArticleIdList><ArticleId IdType="pubmed">9207132</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Chem Soc. 2009 Dec 30;131(51):18228-9</Citation><ArticleIdList><ArticleId IdType="pubmed">19961173</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Biomater. 2017 Feb;49:272-283</Citation><ArticleIdList><ArticleId IdType="pubmed">27915019</ArticleId></ArticleIdList></Reference><Reference><Citation>J Diabetes Sci Technol. 2008 Sep;2(5):746-59</Citation><ArticleIdList><ArticleId IdType="pubmed">19885257</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2016 Apr;84:144-156</Citation><ArticleIdList><ArticleId IdType="pubmed">26828680</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2008 Jun;8(6):1250-61</Citation><ArticleIdList><ArticleId IdType="pubmed">18444920</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioconjug Chem. 2008 Jul;19(7):1389-95</Citation><ArticleIdList><ArticleId IdType="pubmed">18533707</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2002 Dec 21-28;360(9350):2039-45</Citation><ArticleIdList><ArticleId IdType="pubmed">12504401</ArticleId></ArticleIdList></Reference><Reference><Citation>Ups J Med Sci. 2000;105(2):125-33</Citation><ArticleIdList><ArticleId IdType="pubmed">11095109</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2002 Jun;51(6):1779-84</Citation><ArticleIdList><ArticleId IdType="pubmed">12031965</ArticleId></ArticleIdList></Reference><Reference><Citation>J Dermatolog Treat. 2004 Sep;15(5):280-94</Citation><ArticleIdList><ArticleId IdType="pubmed">15370396</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Commun (Camb). 2015 Jul 7;51(53):10652-5</Citation><ArticleIdList><ArticleId IdType="pubmed">26051448</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biomed Mater Res. 2002 Dec 5;62(3):372-7</Citation><ArticleIdList><ArticleId IdType="pubmed">12209922</ArticleId></ArticleIdList></Reference><Reference><Citation>Mater Sci Eng C Mater Biol Appl. 2017 Sep 1;78:24-31</Citation><ArticleIdList><ArticleId IdType="pubmed">28575981</ArticleId></ArticleIdList></Reference><Reference><Citation>Bioconjug Chem. 2007 Nov-Dec;18(6):1713-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17960873</ArticleId></ArticleIdList></Reference><Reference><Citation>J Control Release. 2017 Jul 28;258:10-21</Citation><ArticleIdList><ArticleId IdType="pubmed">28433740</ArticleId></ArticleIdList></Reference><Reference><Citation>Ups J Med Sci. 2005;110(1):17-55</Citation><ArticleIdList><ArticleId IdType="pubmed">15801685</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplantation. 2009 Sep 15;88(5):624-30</Citation><ArticleIdList><ArticleId IdType="pubmed">19741458</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Diabetes Endocrinol. 2018 Jul;6(7):527-537</Citation><ArticleIdList><ArticleId IdType="pubmed">29776895</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2012 Jun;12(6):1576-83</Citation><ArticleIdList><ArticleId IdType="pubmed">22494609</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(12):e50265</Citation><ArticleIdList><ArticleId IdType="pubmed">23227162</ArticleId></ArticleIdList></Reference><Reference><Citation>BioDrugs. 2001;15(12):833-47</Citation><ArticleIdList><ArticleId IdType="pubmed">11784214</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Transplant. 2011;20(10):1641-7</Citation><ArticleIdList><ArticleId IdType="pubmed">21396171</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes Care. 2011 Nov;34(11):2406-9</Citation><ArticleIdList><ArticleId IdType="pubmed">21926290</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2013 Mar;34(8):2098-106</Citation><ArticleIdList><ArticleId IdType="pubmed">23261215</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2007 Jun 28;356(26):2754-5</Citation><ArticleIdList><ArticleId IdType="pubmed">17596618</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2000 Jun;21(11):1155-64</Citation><ArticleIdList><ArticleId IdType="pubmed">10817268</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes Care. 2018 May;41(5):1001-1008</Citation><ArticleIdList><ArticleId IdType="pubmed">29563196</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2005 Jun;54(6):1755-62</Citation><ArticleIdList><ArticleId IdType="pubmed">15919797</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2005 Jul;54(7):2060-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15983207</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2012 Feb;12(2):322-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22053751</ArticleId></ArticleIdList></Reference><Reference><Citation>Langmuir. 2008 Mar 4;24(5):1924-9</Citation><ArticleIdList><ArticleId IdType="pubmed">18217777</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Treat Rev. 2002 Apr;28 Suppl A:13-6</Citation><ArticleIdList><ArticleId IdType="pubmed">12173407</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2013 Aug;62(8):2674-82</Citation><ArticleIdList><ArticleId IdType="pubmed">23881200</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetologia. 2013 Jul;56(7):1605-14</Citation><ArticleIdList><ArticleId IdType="pubmed">23620058</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8132-7</Citation><ArticleIdList><ArticleId IdType="pubmed">10393960</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2006 Dec;27(34):5828-35</Citation><ArticleIdList><ArticleId IdType="pubmed">16919725</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2002 Feb;51(2):265-70</Citation><ArticleIdList><ArticleId IdType="pubmed">11812731</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Transplant. 2007 Nov;16(10):1039-1048</Citation><ArticleIdList><ArticleId IdType="pubmed">28866924</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Diab Rep. 2013 Oct;13(5):733-44</Citation><ArticleIdList><ArticleId IdType="pubmed">23912763</ArticleId></ArticleIdList></Reference><Reference><Citation>Biotechnol Bioeng. 2018 Jan;115(1):232-245</Citation><ArticleIdList><ArticleId IdType="pubmed">28865118</ArticleId></ArticleIdList></Reference><Reference><Citation>ILAR J. 2013;54(2):196-210</Citation><ArticleIdList><ArticleId IdType="pubmed">24174442</ArticleId></ArticleIdList></Reference><Reference><Citation>Front Med (Lausanne). 2018 Jul 13;5:202</Citation><ArticleIdList><ArticleId IdType="pubmed">30057900</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplant Proc. 2013 Mar;45(2):585-90</Citation><ArticleIdList><ArticleId IdType="pubmed">23267798</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunogenetics. 2010 Dec;62(11-12):773-80</Citation><ArticleIdList><ArticleId IdType="pubmed">20882385</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2018 Jul;171:164-177</Citation><ArticleIdList><ArticleId IdType="pubmed">29698867</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2005 Feb 16;293(7):830-5</Citation><ArticleIdList><ArticleId IdType="pubmed">15713772</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2000 Jul 27;343(4):230-8</Citation><ArticleIdList><ArticleId IdType="pubmed">10911004</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2006 Oct 1;177(7):4794-802</Citation><ArticleIdList><ArticleId IdType="pubmed">16982920</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 1999 Oct;48(10):1907-14</Citation><ArticleIdList><ArticleId IdType="pubmed">10512353</ArticleId></ArticleIdList></Reference><Reference><Citation>Diabetes. 2017 Apr;66(4):970-980</Citation><ArticleIdList><ArticleId IdType="pubmed">28069642</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2011 Nov;32(31):7961-70</Citation><ArticleIdList><ArticleId IdType="pubmed">21831422</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Drug Discov. 2003 Mar;2(3):214-21</Citation><ArticleIdList><ArticleId IdType="pubmed">12612647</ArticleId></ArticleIdList></Reference><Reference><Citation>J Control Release. 2006 Jan 10;110(2):290-295</Citation><ArticleIdList><ArticleId IdType="pubmed">16324765</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2005 Aug;5(8):2037-46</Citation><ArticleIdList><ArticleId IdType="pubmed">15996257</ArticleId></ArticleIdList></Reference><Reference><Citation>Tissue Eng. 2007 Aug;13(8):2133-41</Citation><ArticleIdList><ArticleId IdType="pubmed">17516853</ArticleId></ArticleIdList></Reference><Reference><Citation>Transplantation. 2018 Feb;102(2):240-248</Citation><ArticleIdList><ArticleId IdType="pubmed">28902069</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Transplant. 2008;17(10-11):1257-69</Citation><ArticleIdList><ArticleId IdType="pubmed">19181219</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Transplant. 2006 Aug;6(8):1820-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16780547</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2017 Sep;138:121-130</Citation><ArticleIdList><ArticleId IdType="pubmed">28558297</ArticleId></ArticleIdList></Reference><Reference><Citation>Biomaterials. 2013 Jul;34(21):5019-24</Citation><ArticleIdList><ArticleId IdType="pubmed">23578554</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Biomater. 2010 Jul;6(7):2631-41</Citation><ArticleIdList><ArticleId IdType="pubmed">20109585</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Floride</li></region></list><tree><country name="États-Unis"><region name="Floride"><name sortKey="Stabler, Cherie L" sort="Stabler, Cherie L" uniqKey="Stabler C" first="Cherie L" last="Stabler">Cherie L. Stabler</name></region><name sortKey="Berman, Dora M" sort="Berman, Dora M" uniqKey="Berman D" first="Dora M" last="Berman">Dora M. Berman</name><name sortKey="Berman, Dora M" sort="Berman, Dora M" uniqKey="Berman D" first="Dora M" last="Berman">Dora M. Berman</name><name sortKey="Diaz, Waldo" sort="Diaz, Waldo" uniqKey="Diaz W" first="Waldo" last="Diaz">Waldo Diaz</name><name sortKey="Gattas Asfura, Kerim M" sort="Gattas Asfura, Kerim M" uniqKey="Gattas Asfura K" first="Kerim M" last="Gattás-Asfura">Kerim M. Gattás-Asfura</name><name sortKey="Gattas Asfura, Kerim M" sort="Gattas Asfura, Kerim M" uniqKey="Gattas Asfura K" first="Kerim M" last="Gattás-Asfura">Kerim M. Gattás-Asfura</name><name sortKey="Geary, James" sort="Geary, James" uniqKey="Geary J" first="James" last="Geary">James Geary</name><name sortKey="Giraldo, Jaime A" sort="Giraldo, Jaime A" uniqKey="Giraldo J" first="Jaime A" last="Giraldo">Jaime A. Giraldo</name><name sortKey="Kenyon, Norma S" sort="Kenyon, Norma S" uniqKey="Kenyon N" first="Norma S" last="Kenyon">Norma S. Kenyon</name><name sortKey="Kenyon, Norma S" sort="Kenyon, Norma S" uniqKey="Kenyon N" first="Norma S" last="Kenyon">Norma S. Kenyon</name><name sortKey="Kenyon, Norma S" sort="Kenyon, Norma S" uniqKey="Kenyon N" first="Norma S" last="Kenyon">Norma S. Kenyon</name><name sortKey="Kenyon, Norma S" sort="Kenyon, Norma S" uniqKey="Kenyon N" first="Norma S" last="Kenyon">Norma S. Kenyon</name><name sortKey="Kenyon, Norman M" sort="Kenyon, Norman M" uniqKey="Kenyon N" first="Norman M" last="Kenyon">Norman M. Kenyon</name><name sortKey="Rabassa, Alexander" sort="Rabassa, Alexander" uniqKey="Rabassa A" first="Alexander" last="Rabassa">Alexander Rabassa</name><name sortKey="Stabler, Cherie L" sort="Stabler, Cherie L" uniqKey="Stabler C" first="Cherie L" last="Stabler">Cherie L. Stabler</name><name sortKey="Willman, Melissa A" sort="Willman, Melissa A" uniqKey="Willman M" first="Melissa A" last="Willman">Melissa A. Willman</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/RapamycinFungusV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000019 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000019 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= RapamycinFungusV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:31597005
|texte= Transplantation of PEGylated islets enhances therapeutic efficacy in a diabetic nonhuman primate model.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31597005" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a RapamycinFungusV1
| This area was generated with Dilib version V0.6.38. |  |